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Relevance of DNA Alkylation Damage Repair Systems in Salmonella enterica Virulence

Year: 2010

Type: article

Abstract: Systematic inactivation of pathways involved in DNA alkylation damage repair demonstrated that inactivation of the ada, ogt, tag, uvrA, and mfd genes is required to detect a Salmonella enterica virulence decrease. Furthermore, the fitness of S. enterica, defective in these genes, is lowered only when the bacterium is orally, but not intraperitoneally, inoculated.

Source: Journal of Bacteriology

DOI: 10.1128/jb.01693-09

Authors: Gerard Àlvarez, Susana Campoy, Denis A. Spricigo, Laura Teixidó, Pilar Cortés, Jordi Barbé

Institution: Universitat Autònoma de Barcelona

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2096005296

FWCI: 0.139

Cites: 25

Cited by: 7

Related to: 10