Work

Sequence of the haemagglutinin‐neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM)

Year: 1996

Type: article

Abstract: The nucleotide sequence of the haemagglutinin-neuraminidase (HN) glycoprotein gene of Newcastle disease virus (NDV) variant strain V4(UPM) was determined by direct genomic RNA sequencing and confirmed by cycle sequencing. The gene comprises 1996 nucleotides encoding a 615 amino acid protein of size 67.4 kDa. The nucleotide and amino acid sequences of this strain were compared with those of the parent strain V4(QUE). There are 16 nucleotide substitutions on V4(UPM), eight of which are silent mutations and another eliminated a potential Asn-linked glycosylation site in V4(UPM). In addition, an Arg (403) residue was shown to be absent in the variant strain. This deletion is thought to be significant because of its location in a highly conserved region of the HN protein.

Source: Avian Pathology

DOI: 10.1080/03079459608419185

Authors: Khatijah Yusoff, Wen Siang Tan, Chin Hoon Lau, Ban Kim Ng, Abdul Latif Ibrahim

Institution: Universiti Putra Malaysia

Language: English

Topic: Virology and Viral Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: Ministerio de Ciencia, Tecnología y Medio Ambiente

OpenAlex ID: W2097200426

FWCI:

Cites: 16

Cited by: 30

Related to: 10