Work

The dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis

Year: 2005

Type: article

Abstract: Animal models of colorectal carcinogenesis represent invaluable research tool for investigating colorectal cancer (CRC). Experimentally induced tumours in laboratory animals provide opportunity for studying certain aspects of tumours that cannot be effectively studied in humans. Significant information on human CRC aetiology or factors influencing it has derived from studies using dimethylhydrazine (DMH) model that is one of the experimental models appreciated for its morphological similarity to human CRC. Today, DMH model represents useful research tool for the studies of colon carcinogens and chemopreventive agents. The review offers insight into morphogenesis and genetic alterations of DMH induced colorectal epithelial tumours in rats.

Source: DiRROS repository (University of Maribor)

Authors: Martina Perše, Anton Cerar

Institution: University of Ljubljana

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W2097476366

FWCI: 0.109

Cites: 51

Cited by: 45

Related to: 10