Ultrasound features of medullary thyroid carcinoma correlate with cancer aggressiveness: a retrospective multicenter study
Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Poor prognosis of medullary thyroid cancer (MTC) with suspicious ultrasound (US) features has been reported. The aim of the study was to investigate the association between preoperative US presentation and aggressiveness features of MTC. Also, US features of MTC were compared with those previously reported. METHODS: Study group comprised 134 MTC from nine different centers. Based on US presentation the nodules were stratified in "at risk for malignancy" (m-MTC) or "probably benign" (b-MTC) lesions. RESULTS: Eighty nine (66.4%) m-MTC and 45 (33.6%) b-MTC were found. Metastatic lymph nodes (p = 0.0001) and extrathyroid invasiveness (p < 0.0001) were more frequent in m-MTC. There was statistically significant correlation (p = 0.0002) between advanced TNM stage and m-MTC with an Odds Ratio 5.5 (95% CI 2.1-14.4). Mean postsurgical calcitonin values were 224 ± 64 pg/ml in m-MTC and 51 ± 21 in b-MTC (p = 0.003). CONCLUSIONS: This study showed that sonographically suspicious MTC is frequently associated with features of aggressiveness, suggesting that careful preoperative US of MTC patients may better plan their surgical approach.
Authors: Pierpaolo Trimboli, Luca Giovanella, Stefano Valabrega, Massimiliano Andrioli, Roberto Baldelli, Nadia Cremonini, Fabio Rossi, Leo Guidobaldi, Agnese Barnabei, Francesca Rota, Antonella Paoloni, Laura Rizza, Giorgio Fattorini, Maurizio Latini, Claudio Ventura, Paolo Falasca, Fabio Orlandi, Anna Crescenzi, Ferdinando D¿Ambrosio, Vito Cantisani, Francesco Romanelli, Roberto Negro, Enrico Saggiorato, Marialuisa Appetecchia
Institutions: Ospedale Israelitico, Istituto Oncologico della Svizzera Italiana, Azienda Ospedaliera Sant'Andrea, Sapienza University of Rome, Instituto Nazionale Tumori Regina Elena, Ospedale Maggiore Carlo Alberto Pizzardi, Azienda USL di Bologna, University of Turin, Campus Bio Medico University Hospital, Ospedale Vito Fazzi
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
OpenAlex ID: W2098351663