Pandemic (H1N1) 2009 influenza in the UK: clinical and epidemiological findings from the first few hundred (FF100) cases
Year: 2010
Type: article
Study design: Observational Study
Abstract: The UK was one of few European countries to document a substantial wave of pandemic (H1N1) 2009 influenza in summer 2009. The First Few Hundred (FF100) project ran from April-June 2009 gathering information on early laboratory-confirmed cases across the UK. In total, 392 confirmed cases were followed up. Children were predominantly affected (median age 15 years, IQR 10-27). Symptoms were mild and similar to seasonal influenza, with the exception of diarrhoea, which was reported by 27%. Eleven per cent of all cases had an underlying medical condition, similar to the general population. The majority (92%) were treated with antiviral drugs with 12% reporting adverse effects, mainly nausea and other gastrointestinal complaints. Duration of illness was significantly shorter when antivirals were given within 48 h of onset (median 5 vs. 9 days, P=0.01). No patients died, although 14 were hospitalized, of whom three required mechanical ventilation. The FF100 identified key clinical and epidemiological characteristics of infection with this novel virus in near real-time.
Source: Epidemiology and Infection
Authors: E. McLEAN, R. G. PEBODY, C. CAMPBELL, M. CHAMBERLAND, C. HAWKINS, J. S. NGUYEN-VAN-TAM, I. OLIVER, G. E. SMITH, C. IHEKWEAZU, S. BRACEBRIDGE, H. MAGUIRE, R. HARRIS, G. KAFATOS, P. J. WHITE, E. WYNNE-EVANS, J. GREEN, R. MYERS, A. UNDERWOOD, T. DALLMAN, T. WREGHITT, M. ZAMBON, J. ELLIS, N. PHIN, B. SMYTH, J. McMENAMIN, J. M. WATSON
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2098596394