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pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

Year: 2010

Type: article

Abstract: We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification. This case raises the question of the presence and the evolution of this genotype in Africa, which is also known to alter the susceptibility to artemisinin combination therapy (ACT).

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.01057-10

Authors: Benoit Witkowski, Xavier Iriart, Patrice Njomnang Soh, Sandie Menard, Muriel Alvarez, Veronique Naneix-Laroche, Bruno Marchou, Jean-François Magnaval, Françoise Benoit-Vical, Antoine Berry

Institutions: Centre National de la Recherche Scientifique, Université Toulouse III - Paul Sabatier, Centre Hospitalier Universitaire de Toulouse, Laboratoire de Chimie de Coordination, Hôpital Rangueil, Université de Toulouse

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2098697213

FWCI: 3.173

Cites: 25

Cited by: 18

Related to: 10