Work

Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies

Year: 2014

Type: article

Abstract: Increased understanding of intertumoral heterogeneity at the genomic level has led to significant advancements in the treatment of solid tumors. Functional genomic alterations conferring sensitivity to targeted therapies can take many forms, and appropriate methods and tools are needed to detect these alterations. This review provides an update on genetic variability among solid tumors of similar histologic classification, using non-small cell lung cancer and melanoma as examples. We also discuss relevant technological platforms for discovery and diagnosis of clinically actionable variants and highlight the implications of specific genomic alterations for response to targeted therapy.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-13-1591

Authors: Catherine B. Meador, Christine M. Micheel, Mia A. Levy, Christine M. Lovly, Leora Horn, Jeremy L. Warner, Douglas B. Johnson, Zhongming Zhao, Ingrid A. Anderson, Jeffrey A. Sosman, Cindy L. Vnencak-Jones, Kimberly B. Dahlman, William Pao

Institutions: Vanderbilt University, Vanderbilt-Ingram Cancer Center

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, National Institutes of Health, U.S. Food and Drug Administration, National Cancer Institute, National Institute of General Medical Sciences, U.S. National Library of Medicine

Awards: G153582612, G1827975024, G1949395773, G2065572564, G2146954135, G2684890037, G290007438, Overcoming acquired resistance to EGFR inhibitors in lung cancer, Medical Scientist Training Program, G4342453648, G435997112, G457800531, Evolutionary Dynamics of Brain, Lung, and Hematopoietic Tumors, G725763919, G771694649, Vanderbilt Clinical Oncology Research Career Development Award

OpenAlex ID: W2102007289

FWCI: 3.11

Cites: 111

Cited by: 67

Related to: 10