A G Protein-coupled Receptor for UDP-glucose
Year: 2000
Type: article
Abstract: Uridine 5'-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is less well known that UDP-glucose may possess pharmacological activity, suggesting that a receptor for this molecule may exist. Here, we show that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells. Nucleotides known to activate P2Y receptors were inactive, indicating the distinctly novel pharmacology of this receptor. The receptor is expressed in a wide variety of human tissues, including many regions of the brain. These data suggest that some sugar-nucleotides may serve important physiological roles as extracellular signaling molecules in addition to their familiar role in intermediary metabolism.
Source: Journal of Biological Chemistry
Authors: Jon K. Chambers, Lynn E. Macdonald, Henry M. Sarau, Robert S. Ames, Katie Freeman, James J. Foley, Yuan Zhu, Megan M. McLaughlin, Paul Murdock, Lynette McMillan, John Trill, Ann Swift, Nambi Aiyar, Paul Taylor, Lisa Vawter, Sajda Naheed, Philip Szekeres, Guillaume Hervieu, Claire Scott, Jeanette M. Watson, Andrew J. Murphy, Emir Duzic, Christine Klein, Derk J. Bergsma, Shelagh Wilson, George P. Livi
Institution: GlaxoSmithKline (United Kingdom)
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2102223391