Year: 2013
Type: article
Abstract: Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replicated efficiently in explants from tracheas and bronchi, with limited replication in alveolar cells. Swine respiratory tissue explants can serve as an efficient model for screening replication potential of newly emerging H7N9 viruses.
Source: Journal of Virology
DOI: 10.1128/jvi.02499-13
Institutions: St. Jude Children's Research Hospital, Shantou University, Shantou University Medical College, Shenzhen Third People’s Hospital, University of Hong Kong, Chinese Center For Disease Control and Prevention, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: G1309367075
OpenAlex ID: W2104098707