Work

SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans

Year: 2013

Type: review

Abstract: Simian immunodeficiency virus (SIV) infection of Indian-origin rhesus macaques (RM) has been widely used as a well-established nonhuman primate (NHP) model for HIV/AIDS research. However, there have been a growing number of studies using Chinese RM to evaluate immunopathogenesis of SIV infection. In this paper, we have for the first time reviewed and discussed the major publications related to SIV or SHIV infection of Chinese RM in the past decades. We have compared the differences in the pathogenesis of SIV infection between Chinese RM and Indian RM with regard to viral infection, immunological response, and host genetic background. Given AIDS is a disease that affects humans of diverse origins, it is of importance to study animals with different geographical background. Therefore, to examine and compare results obtained from RM models of Indian and Chinese origins should lead to further validation and improvement of these animal models for HIV/AIDS research.

Source: Retrovirology

DOI: 10.1186/1742-4690-10-89

Authors: Yu Zhou, Rong Bao, Nancy L Haigwood, Yuri Persidsky, Wen-zhe Ho

Institutions: Wuhan University, State Key Laboratory of Virology, Temple University, Oregon National Primate Research Center, Oregon Health & Science University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890