The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5‐Lipoxygenase on Anaphylactic and Inflammatory Responses
Year: 1988
Type: review
Abstract: In conclusion, we have described a novel series of acetohydroxamic acids that are potent and selective inhibitors of arachidonate 5-lipoxygenase in vitro and in vivo. In addition, we have shown that these compounds attenuate "leukotriene-dependent" anaphylactic bronchospasm, the accumulation of inflammatory leukocytes, and the development of fever in experimental models. It now remains to be determined if these compounds have any therapeutic value in man.
Authors: P. BHATTACHERJEE, N. K. BOUGHTON‐SMITH, R. L. FOLLENFANT, L. G. GARLAND, G. A. HIGGS, H. F. HODSON, P. J. ISLIP, W. P. JACKSON, S. MONCADA, A. N. PAYNE, R. W. RANDALL, C. H. REYNOLDS, J. A. SALMON, J. E. TATESON, B. J. R. WHITTLE
Institution: Wellcome Trust
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2104934612