Work

Cytogenetic and molecular analysis of chromosome instability in cattle with reproductive problems / Cytogenetyczna i molekularna analiza niestabilności chromosomów u bydła z problemam w rozrodzie

Year: 2013

Type: article

Abstract: The cytogenetic and molecular analysis of cattle chromosome instability revealed excessive fragility of chromosome X in q11, q24, q31 and p13 regions in cows with reproductiveproblems. The highest frequency of structural defects was found in BTAXp13 region containing FRM1 gene locus with unstable trinucleotide CGG repeats which were mapped by in situ PCRmethod. The results obtained suggest that chromosome X structural instability may be a cause of defective expression of genes related with fertility and it leads to a decrease of reproductive efficiency. The present outcomes can be used in further studies on the cytogenetic and molecular substructure of chromosome instability phenomenon and their phenotypic effects in cattle.

Source: Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica

DOI: 10.2478/v10083-012-0027-8

Authors: Barbara Danielak-Czech, Marek Babicz, Barbara Rejduch, Anna Kozubska-Sobocińska

Institutions: National Research Institute of Animal Production, University of Life Sciences in Lublin

Language: Polish

Topic: Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Zero hunger

Open Access status: diamond

OpenAlex ID: W2105931992

FWCI: 0.165

Cites: 17

Cited by: 6

Related to: 10