Work

Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue

Year: 2011

Type: article

Abstract: In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their applicability in a few examples from in vivo open brain surgery.

Source: IEEE photonics journal

DOI: 10.1109/jphot.2011.2141656

Authors: M Brydegaard, N Haj-Hosseini, K Wårdell, S Andersson-Engels

Institutions: Lund University, Linköping University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2107225293

FWCI: 1.057

Cites: 59

Cited by: 19

Related to: 10