Work

SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences

Year: 2006

Type: article

Abstract: The single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNP@Domain, a web resource, to identify SNPs within human protein domains. We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains: (i) structure-based using SCOP and (ii) sequence-based using Pfam to avoid conflicts from two domain assignment methodologies. Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNP@Domain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.

Source: Nucleic Acids Research

DOI: 10.1093/nar/gkl323

Authors: A. Han, H. J. Kang, Y. Cho, S. Lee, Y. J. Kim, S. Gong

Institution: Korea Research Institute of Bioscience and Biotechnology

Language: English

Topic: Genomics and Rare Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,992

OpenAlex ID: W2107477403