Work

New cephalosporins with 7-acyl groups derived from .BETA.-ketoacids. I. 7-(.BETA.-Ketoacylamino)cephalosporins.

Year: 1978

Type: article

Abstract: The synthesis and antimicrobial profile of a series of 7-(beta-ketoacylamino)cephalosporins (1) bearing an acetoxymethyl or a heterocyclichiomethyl group at the 3-position are described. Of this series, 3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-7-(3-oxobutyrylamino)ceph-3-em-4-carboxylic acid (11) showed moderate antibacterial activities in in vitro and in vivo tests.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.31.1245

Authors: MITSUO NUMATA, MASAYOSHI YAMAOKA, ISAO MINAMIDA, MASAAKI KURITANI, YOSHIO IMASHIRO

Institution: Takeda (Japan)

Language: English

Topic: Synthesis of β-Lactam Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2107628612

FWCI: 0.587

Cites: 11

Cited by: 5

Related to: 10