Year: 1971
Type: article
Abstract: In 2 cases of old dog encephalitis (ODE), viral antigen to canine distemper was demonstrated in frozen brain tissue by means of the direct FA test. The distemper viral antigen was most abundant in cells of the gray matter of the cerebral cortex, thalamus, mesencephalon, and medulla. Also, in the 1 dog in which serum was available, there was a significantly elevated serum antibody titer to the distemper agent. Attempts to isolate a viral agent in tissue culture or to transmit disease to distemper-susceptible ferrets or distemper-immune adult dogs were unsuccessful. Results of this study indicate that the virus of distemper play a role in the pathogenesis of ODE. Also, the progressive disease with inflammatory reaction suggests that a slow viral infection rather than a totally masked or latent virus be involved.
Source: Veterinary Pathology
Language: English
Topic: Virology and Viral Diseases
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Institutes of Health
OpenAlex ID: W2107754387