Work

Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine

Year: 2014

Type: article

Abstract: Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02889-14

Authors: Alice C. Eziefula, Helmi Pett, Lynn Grignard, Salome Opus, Moses Kiggundu, Moses R. Kamya, Shunmay Yeung, Sarah G. Staedke, Teun Bousema, Chris Drakeley

Institutions: London School of Hygiene & Tropical Medicine, Radboud University Medical Center, Infectious Diseases Research Collaboration, Makerere University

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,421

Funder: Wellcome Trust

Awards: Wellcome Trust Bloomsbury Centre for Global Health Research., Wellcome Trust Clinical PhD Programme in International Health at the LSHTM: 'Evaluation of the efficacy and safety of primaquine for clearance of gametocytes in uncomplicated falciparum malaria: a randomised clinical trial'.

OpenAlex ID: W2107918320

FWCI: 4.526

Cites: 14

Cited by: 42

Related to: 10