Work

Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector

Year: 2008

Type: article

Abstract: A bare graphite-polyurethane composite was evaluated as an amperometric flow injection detector in the determination of paracetamol (APAP) in pharmaceutical formulations. A linear analytical curve was observed in the 5.00 x 10-5 to 5.00 x 10-3 mol L-1 range with a minimum detectable net concentration of 18.9 µmol L-1 and 180 determinations h-1, after optimization of parameters such as the detection potential, sample loop volume, and carrier solution flow rate. Interference of ascorbic acid was observed, however, it was possible overcome the interference, reaching results that agreed with HPLC within 95% confidence level. These results showed that the graphite-polyurethane composite can be used as an amperometric detector for flow analysis in the determination of APAP.

Source: Journal of the Brazilian Chemical Society

DOI: 10.1590/s0103-50532008000500005

Authors: Priscila Cervini, Éder Tadeu Gomes Cavalheiro

Institutions: Universidade de São Paulo, Instituto de Química de São Carlos

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $275