Year: 2008
Type: article
Abstract: in this journal [1] concerning a 12-year-old boy who developed severe chest pain after oral administration of 5-aminosalicylic acid (5-ASA, mesalamine).Electrocardiographic changes during the pain were not specific but inverted T-waves were present in the lateral chest leads.Additionally, cardiac enzymes, troponins, C-reactive protein and brain natriuretic peptide were normal.The authors concluded that this patient had suffered a rare hypersensitivity reaction to mesalamine.It is known that mesalamine can, rarely, induce hypersensitivity reactions such as hypersensitivity myocarditis, hypersensitivity pneumonitis, angioedema, pericarditis, erythroderma, toxic epidermal necrolysis, palmar-plantar erythrodysesthesia, skin rashes and hypereosinophilia.This case seems to be a characteristic case of typeⅠ variant of Kounis syndrome [2,3] , the youngest reported so far.Another case of Kounis syndrome secondary to amoxicillin/clavulanic acid use has been recently reported in a 13-year-old child [4] .On the other hand, salicylate products such as aspirin are known to induce hypersensitivity reactions, and aspirin has been reported to induce Kounis syndrome [5] .Pathophysiologically, symptoms of salicylate hypersensitivity can be explained by over-production of leukotriene metabolites, since salicylate allergic patients who have come in contact with salicylates show a marked inhibition of cyclooxygenase (COX), which is continuously expressed in the human body.This leads to a diminished production of COX products such as prostacyclin and thromboxane, and can accelerate the metabolism of arachidonic acid towards lipoxygenase products such as leukotrienes.It is known that leukotrienes are powerful coronary arterial vasoconstrictors, and their biosynthesis is enhanced in the acute phase of unstable angina [2] .Atay et al [1] have correctly stated that arachidonic acid metabolites generated through both COX and lipoxygenase pathways are thought to be increased in patients with ulcerative colitis.Ideally, in this case, allergic screening with measurement of mast cell mediators such as histamine and arachidonic acid metabolites should have been carried out.However, this study shows that Kounis syndrome is not a very rare disease but a 'very rarely diagnosed' disease.
DOI: 10.3748/wjg.14.7141
Institution: International Medical Information Center
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2108386352