Work

Synthesis of 2-amino-1,4-benzodiazepin-5-ones from 2-nitrobenzoic acid and α-aminonitriles

Year: 2011

Type: article

Abstract: Condensation of α-aminonitriles with 2-nitrobenzoyl chloride gives the corresponding Schiff bases, which furnish, upon reduction with Zn, the corresponding 2-amino-3,4-dihydro-5H-1,4benzodiazepin-5-ones.However, reduction of the Schiff base obtained from the condensation of 1-aminocyclohexanecarbonitrile with 2-nitrobenzaldehyde gives the methanol adduct of 2aminobenzaldehyde trimer.

Source: ARKIVOC

DOI: 10.3998/ark.5550190.0012.226

Authors: Eyad A. Younes, Ahmad Q. Husseina, Mitchell A. May, Frank R. Fronczek

Institutions: University of Jordan, Louisiana State University

Language: English

Topic: Synthesis and pharmacology of benzodiazepine derivatives

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Deanship of Academic Research, University of Jordan, University of Jordan

OpenAlex ID: W2108416366

FWCI: 0.555

Cites: 2

Cited by: 12

Related to: 10