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Inflammation, Immunity, and Cancer: The Role of Transcription Factors NF-kB and STAT3

Year: 2010

Type: article

Abstract: A link between inflammation and cancer has long been suspected. Recent studies have identified the role of transcription factors nuclear factor-kB (NF-kB) and signal transducer and activator of transcription 3 (STAT3) in inflammation-induced tumor. In this review, we focus on the role of NF-kB and STAT3 in regulating functions of cancer cells and surrounding nontumorigenic cells to create a tumor microenvironment that enhance tumor promotion and progression. Key word: inflammation, cancer, NF-kB, STAT3

Source: Journal Of The Indonesian Medical Association

Authors: Khie Khiong, Oeij Anindita Adhika, Melisa Chakravitha

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2111117543

FWCI:

Cites: 18

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Related to: 10