Work

Immunoglobulins and complement components in synovial fluid of patients with acute rheumatic fever.

Year: 1975

Type: article

Abstract: A B S T R A C T Three components of complement and six other serum proteins were assayed in synovial fluid and serum samples from 25 patients with acute rheu- matic fever in Trinidad.The resulting data indicate a relative decrease in both early and late components of complement within the synovial fluids which suggests local activation by immune complexes.Such activation of complement within the joint spaces may play a pri- mary role in development of the inflammatory arthritis of acute rheumatic fever. METHODSClinical material.25 patients with joint effusion and ARF on the basis of the modified Jones criteria (1) underwent

Source: Journal of Clinical Investigation

DOI: 10.1172/jci108059

Authors: M Svartman, E V Potter, T Poon-King, D P Earle

Institutions: Northwestern University, San Fernando General Hospital

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Otho S. A. Sprague Memorial Institute, National Institutes of Health