Work

A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds

Year: 2015

Type: article

Abstract: A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201501538

Authors: Jian‐Siang Poh, Duc N. Tran, Claudio Battilocchio, Joel M. Hawkins, Steven V. Ley

Institutions: University of Cambridge, Pfizer (United States)

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,510

Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Engineering and Physical Sciences Research Council