Work

Good Clinical Outcomes but High Rates of Adverse Reactions during Linezolid Therapy for Serious Infections: a Proposed Protocol for Monitoring Therapy in Complex Patients

Year: 2006

Type: article

Abstract: We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29+/-28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n=13; anemia, n=7; gastrointestinal, n=12; peripheral neuropathy, n=1; serotonin syndrome, n=1), such that a systematic monitoring protocol was developed.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.50.4.1599-1602.2006

Authors: Emma Bishop, Sharmila Melvani, Benjamin P. Howden, Patrick G. P. Charles, M. Lindsay Grayson

Institutions: Austin Hospital, Austin Health, Monash University, The University of Melbourne

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2113662648

FWCI: 9.336

Cites: 20

Cited by: 144

Related to: 10