[Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs].
Year: 2008
Type: article
Abstract: Cytochrome P450 enzymes are very important to metabolize anti-carcinogenic agents. Therefore, understanding the role of these enzymes and their allele variants in the bioactivation or detoxification of drugs could greatly benefit antineoplastic pharmacotherapy. The aim of this manuscript is to give information about metabolizing enzymes for antineoplastic agents and to relate the current situation in antitumoral pharmacotherapy with recent knowledge about cytochrome P450 enzymes. This is crucial for the future perspectives towards personalized pharmacotherapy. We summarize the role of cytochrome P450 enzymes in the resistance and bioactivation of several antitumor agents, their induction and repression mechanisms and the effect of genetic polymorphisms on variability of drug metabolization. The understanding of genetic variability will help to develop new research lines on innovative therapeutic possibilities.
Source: PubMed
Authors: Luis Quiñones S, Mario Rosero P, Angela Roco A, Iván Moreno T, Jaime Sasso A, Nelson Varela F, Dante Cáceres L, Iván Saavedra S
Institutions: Hospital San Juan de Dios, University of Chile
Language: Spanish
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2117572576