Year: 2008
Type: conference-paper
Abstract: We consider a biological cell as a highly nterconnected network of chemical reactions, which is constituted of a large number of semi-autonomous functional modules. Depending on the global state of the network, the separate functional modules may display qualitatively different behavior. As an example, we study a conceptual network of phosphorylation cycles, for which the steady-state concentration of an output compound depends on the concentrations of two input enzymes. We show that the input-output relation depends on the expression of the proteins in the network. Hence changes in protein expression, due to changes in the global regulatory network of the cell, can change the functionality of the module. In this specific example, changed expression of two proteins is sufficient to switch between the functionalities of various logical gates.
Source: TU/e Research Portal
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: European Commission
OpenAlex ID: W2118929117