Year: 1992
Type: article
Abstract: PIVKA-II concentrations in patients with cystic fibrosisMontalembert et al report that PIVKA-II was detected in 33% of patients with cystic fibrosis, while vitamin K, plasma concentra- tions were normal.'It is astonishing that despite daily supplements of 5-10 mg vita- min K,, PIVKA-II was detectable in these patients.The authors conclude that PIVKA- II is not associated with vitamin K deficiency, but with the use of antibiotics.There is some doubt as to whether the assay for PIVKA-II used by the authors is reliable.Widdershoven et al compared differ- ent methods for measuring PIVKA-II and reported that techniques involving adsorption of normal factor II may result in false positive values, because the carboxylated prothrombin may not be removed com- pletely.2Determination of PIVKA-II by monoclonal antibody was found to be the most specific and sensitive method.2We did not detect PIVKA-II in any of eight patients with cystic fibrosis who were supplemented with vitamin K, (4-30 mg/day).3In only one out of 16 unsupplemented patients with cystic fibrosis was PIVKA-II found (0-16 AU/ml).This patient took antibiotics, had a low vitamin K, concentration of 0-06 ,ug/l and a Thrombotest of 56%.3The authors do not mention vitamin K,.Except for vitamin K,, vitamin K, must be
Source: Journal of Clinical Pathology
Author: T E Blecher
Language: English
Topic: Vitamin K Research Studies
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2118933235