Prostate cancer prevention: review of target populations, pathological biomarkers, and chemopreventive agents.
Year: 1999
Type: review
Abstract: Chemoprevention is the administration of agents to prevent induction of cancer, or to inhibit or delay its progression.1 In prostatic neoplasia, the time from tumour initiation and progression to invasive carcinoma often begins in men in the fourth and fifth decades of life and extends across decades.This phenomenon represents a unique opportunity to arrest or reverse the process of carcinogenesis with the use of chemopreventive agents.For prostate cancer, as for other cancer targets, development of successful chemopreventive strategies requires suitable cohorts, reliable biomarkers for evaluating chemopreventive eYcacy, and well characterised agents. 1 Histopathologists have an important role in prostate chemoprevention.They define the high risk groups, recognise the surrogate end markers, and evaluate the morphological eVects of the agents on the prostate tissue specimens.
Source: Journal of Clinical Pathology
Institutions: University of Arizona, University of Arizona Cancer Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2118964444