Work

Characterization of DNA-Nanopore Interactions by Molecular Dynamics

Year: 2009

Type: article

Abstract: A major challenge in using solid-state nanopores for DNA detection and sequencing is the molecular selectivity and sensitivity resolution through proper control of DNA-nanopore interface.This paper explores the interaction mechanisms between DNA and nanopores through molecular dynamics simulations.The DNA translocation dynamics through nanopores of various diameters and under various applied biasvoltages are characterized.Such property-function relationship can be used for the optimal designs of the lab-on-chip DNA diagnostic devices.

Source: American Journal of Biomedical Sciences

DOI: 10.5099/aj090400344

Authors: Abhijit Ramachandran, Yaling Liu, Waseem Asghar, Samir Iqbal

Institution: The University of Texas at Arlington

Language: English

Topic: Nanopore and Nanochannel Transport Studies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, University of Texas at Arlington

OpenAlex ID: W2120949014

FWCI: 1.559

Cites: 35

Cited by: 22

Related to: 10