Work

Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells

Year: 1997

Type: article

Abstract: Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.41.11.2566

Authors: J R Lokensgard, G Gekker, S Hu, A F Arthur, C C Chao, P K Peterson

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Mental Health, National Institute on Drug Abuse

Awards: ANXIOLYTIC DRUGS EFFECTS ON HIV1 NEUROPATHOGENESIS, Modulation of Cell-Mediated Immune Function by Opiates