Year: 1989
Type: article
Abstract: Rabbit anti-rat thymocyte antiserum (ARTS) and monoclonal anti-Thy-l.lantibody (Thy-l.lmAb) were used in the absorption assay and complement-dependent cytotoxic test to define the antigenic relationship between rats and Mongolian gerbils.ARTS was absorbed by the gerbil brain and thymocytes and lost its cytotoxicity on rat thymocytes.Thy-l.lmAb was also absorbed by gerbil thymocytes, but not by spleen cells.Immunofluorescent studies showed that cortical thymocytes were strongly positive to both antibodies, whereas medullary thymocytes exhibited a weakly positive reaction.In the spleen and lymph nodes, only a small number of Thy-l.lantigen-positive cells were observed.In the kidney, a positive reaction to both antibodies was observed in the glomerular mesangial region.The results indicate that the Thy-l.lantigen exists in Mongolian gerbils, and its distribution in tissues is similar to that in rats.
Source: Biomedical Research
Institution: Nippon Medical School
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2122829347