Work

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid‐Anchored Peptide Vaccines

Year: 2013

Type: article

Abstract: Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201303374

Authors: Eline J. Koers, Maria Pilar López‐Deber, Markus Weingarth, Deepak Nand, David T. Hickman, Dorin Mlaki Ndao, Pedro Reis, Anne Granet, Andrea Pfeifer, Andreas Muhs, Marc Baldus

Institutions: Utrecht University, AC Immune (Switzerland), École Polytechnique Fédérale de Lausanne

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2122844166

FWCI: 2.66

Cites: 22

Cited by: 46

Related to: 10