Work

Aspochalamins A-D and Aspochalasin Z Produced by the Endosymbiotic Fungus Aspergillus niveus LU 9575: II. Structure Elucidation

Year: 2004

Type: article

Abstract: The structures of new cytochalasan fungal metabolites aspochalamins A-D have been elucidated by ESI-FTICR-MS, NMR spectroscopy, and chiral amino acid analysis. Aspochalamins A-D consist of different aspochalasin skeletons connected at position C-19 to the N terminus of the tripeptidic moiety amide anthranoyl-L-alanine-E-didehydrotryptamide. Furthermore, the structure of a new aspochalasin analog, aspochalasin Z, was derived from its molecular mass and NMR data as 10-isopropyl-14-methyl[11]-cytochalasa-6Z,13E,19E-triene-1,21-dione.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.57.715

Authors: ALEXANDRA HÖLTZEL, DIETMAR G. SCHMID, GRAEME J. NICHOLSON, PHILIPP KRASTEL, AXEL ZEECK, KLAUS GEBHARDT, HANS-PETER FIEDLER, GÜNTHER JUNG

Institutions: University of Tübingen, University of Göttingen

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2123709609

FWCI: 0.928

Cites: 18

Cited by: 19

Related to: 10