Human Corticotropin-Releasing Hormone (hCRH) Test: Sex and Age Differences in Plasma ACTH and Cortisol Responses and their Reproducibility in Healthy Adults.
Year: 1993
Type: article
Abstract: The effectiveness and safety of MCI-028, a synthetic human corticotropin-releasing hormone (hCRH), as a diagnostic drug were examined in 65 healthy male and 24 healthy female adult volunteers. Mean maximum concentrations of plasma ACTH and cortisol after intravenous administration of 100 micrograms of MCI-028 were 3.0 and 2.0 times their basal concentrations, respectively, and there were no significant age or sex differences in the responses. Good reproducibility was observed in the responses in 59 male subjects who received a second administration after 1 to 2 weeks. Although slight adverse reactions such as mild and transient hot flushing were observed, these were not serious.
Source: Endocrine Journal
Authors: KOSHI TANAKA, NAOKATA SHIMIZU, HIROO IMURA, JUNICHI FUKATA, ITSURO HIBI, TOSHIAKI TANAKA, SHOICHI NAKAGAWA, KENJI FUJIEDA, KAZUO TAKEBE, KAORU YOSHINAGA, KINTOMO TAKAKURA, SEIZO SUWA, KATSUHIKO TACHIBANA, KIYOHIKO KATO, TERUYA YOSHIMI, KIYOSHI MIURA, AKIO KUWAYAMA, ZENSUKE OTA, YUZURU KATO, SHIRO SAITO, JIRO TAKAHARA, KOZO HASHIMOTO, HAJIME NAWATA, SHIGERU MATSUKURA, NOBORU YANAIHARA
Institutions: Teikyo University, Kyoto University, Children's National, National Children's Hospital, Hokkaido University, Hirosaki University, Tohoku University, Tokyo Women's Medical University, The University of Tokyo, Kanagawa Children's Medical Center, University of Yamanashi, Hamamatsu University, Hamamatsu University School of Medicine, Gifu University, Okayama University, Shimane Medical University, Tokushima University, Kagawa University, Kagawa University Hospital, Kōchi University, Kyushu University, University of Miyazaki, Shizuoka University, University of Shizuoka
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Hirosaki University, Hokkaido University
OpenAlex ID: W2124235302