Work

Detection ofblaSHV,blaTEMandblaCTX-Mantibiotic resistance genes in randomly selected bacterial pathogens from the Steve Biko Academic Hospital

Year: 2009

Type: article

Abstract: Extended-spectrum beta-lactamases (ESBLs) are considered to be one of the most important antibiotic resistance mechanisms. This study reported the ESBL-producing genes in 53 randomly selected clinical bacterial isolates from the Steve Biko Academic Hospital. The presence of the bla(SHV), bla(TEM) and bla(CTX-M) genes was determined, and the overall prevalence of these genes detected in this study was 87% (46/53) in comparison with the literature; these results were higher when compared with 33% for Escherichia coli in Europe and 0.8% in Denmark for similar pathogens. These research findings indicated that it is crucial to routinely monitor the prevalence of these resistance genes.

Source: FEMS Immunology & Medical Microbiology

DOI: 10.1111/j.1574-695x.2009.00564.x

Authors: Marthie M. Ehlers, Chrisna Veldsman, Eddy P. Makgotlho, Michael G. Dove, Anwar A. Hoosen, Marleen M. Kock

Institution: University of Pretoria

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Pretoria, National Health Laboratory Service