Year: 2013
Type: article
Abstract: We examined the change of HSP70 expression in the mouse dental pulp which was exposed to experimental teeth separation by immunohistochemistry as a model for conservative dental treatment. Eight week-old 18 male ddY mice were used and a wedge was inserted between upper 1st and 2nd molars for 3 hours. In the experimental group, HSP70 expression increased in the dental pulp tissues. The expression was the greatest at 24 hours after which it gradually decreased to become similar to the level of the control group at 1 week. These results suggest that when immunohistochemical expression of HSP70 is used as an index, almost no severe damage occurs upon clinical application of a wedge insertion.
Source: Journal of Hard Tissue Biology
DOI: 10.2485/jhtb.22.7
Institution: Matsumoto Dental University
Language: English
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Molecular control mechanism of cell suppling, migration and differentiation in remodeling of periodontal ligament, Elucidation of the cell differentiation molecular regulation mechanism in proliferative lesions of the oral cavity using bone marrow stem cell transplantation model, 傷害性ストレスに対する歯髄細胞の恒常性維持と回復反応に関する分子機構の解明, Elucidation of the molecular mechanisms of tissue repair using stem cells, Elucidation of molecular regulation mechanism and promotion of the orthodontic remodeling using the bone marrow stem cell
OpenAlex ID: W2124709554