Work

Reductive Ligation Mediated One-Step Disulfide Formation of S-Nitrosothiols

Year: 2010

Type: article

Abstract: A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.

Source: Organic Letters

DOI: 10.1021/ol101863s

Authors: Jiming Zhang, Sheng Li, Dehui Zhang, Hua Wang, A. Richard Whorton, Ming Xian

Institutions: Duke University, Duke Medical Center, Washington State University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Awards: G6624852830, Regulation of Rho Signaling by S-Nitrosothiols