Work

The Tandem Repeated Irritation Test: A New Method to Assess Prevention of Irritant Combination Damage to the Skin

Year: 2002

Type: article

Abstract: The effect of a protective cream was tested in a new tandem repeated irritation test with tandem application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene. The irritants were applied twice daily for 30 min to the ventral forearms of 20 volunteers. Irritant cutaneous reactions were quantified by a visual score, transepidermal water loss, chromametry and skin capacitance. Concurrent application of SLS/toluene induced stronger reactions than those caused by twice daily application of each irritant on its own. A protective effect of the protective cream was obtained against all treatment combinations and was significant for SLS/SLS (p < or = 0.01) and SLS/ toluene (p < or = 0.05). Our results indicate that the tandem repetitive irritation test has great potential in the evaluation of skin care products to prevent irritant contact dermatitis.

Source: Acta Dermato Venereologica

DOI: 10.1080/00015550252948103

Authors: Walter Wigger-Alberti, Julia Spoo, Sibylle Schliemann-Willers, Andreas Klotz, Peter Elsner

Institution: Friedrich Schiller University Jena

Language: English

Topic: Contact Dermatitis and Allergies

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,725