Year: 2010
Type: article
Abstract: Among various DNA damages, double-strand breaks (DSBs) are considered as most deleterious, as they may lead to chromosomal rearrangements and cancer when unrepaired. Nonhomologous DNA end joining (NHEJ) is one of the major DSB repair pathways in higher organisms. A large number of studies on NHEJ are based on in vitro systems using cell-free extracts. In this paper, we summarize the studies on NHEJ performed by various groups in different cell-free repair systems.
Source: Journal of Nucleic Acids
DOI: 10.4061/2010/389129
Authors: Sheetal Sharma, Sathees C. Raghavan
Institution: Indian Institute of Science Bangalore
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,000
Awards: G7571355246, G81566887
OpenAlex ID: W2129189161