Work

Persistent Region-Dependent Neuroinflammation, Nmda Receptor Loss and Atrophy In An Animal Model of Penetrating Brain Injury

Year: 2012

Type: article

Abstract: Dynamic changes in neuroinflammation and glutamate NMDA receptors (NMDAR) have been noted in traumatic and ischemic brain injury. Aim: Here we investigate the time course and regional distribution of these changes and their relationship with atrophy in a rat model of penetrating brain injury. Materials & methods: Quantitative autoradiography, with the neuroinflammation marker [3H]PK11195 and the NMDAR antagonist [125I]iodoMK801, was performed on brains of animals subjected to a unilateral wireknife injury at the level of striatum and killed 3–60 days later. Regional atrophy was measured by morphometry. Results: The injury produced large increases in [3H]PK11195 binding density in cortical and septal regions adjacent to the knife track by day 7, with modest increases in the striatum. [125I]iodoMK801 binding was reduced in cortical and hippocampal regions showing marked neuroinflammation, which showed marked atrophy at subsequent time points. Conclusion: These results indicate that neuroinflammaton and loss of NMDAR precede and predict tissue atrophy in cortical and hippocampal regions.

Source: Future Neurology

DOI: 10.2217/fnl.12.25

Authors: Rachel Grossman, Charles M Paden, Pamela A Fry, Ryon Sun Rhodes, Anat Biegon

Institutions: Sheba Medical Center, Montana State University, Brookhaven National Laboratory

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke