Work

Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2′- C -Methylcytidine, the Active Component of Valopicitabine

Year: 2006

Type: article

Abstract: Ribavirin antagonizes the in vitro anti-hepatitis C virus (HCV) activity of the pyrimidine nucleoside analogue 2'-C-methylcytidine, the active component of the experimental anti-HCV drug valopicitabine. In contrast, the combination of ribavirin with either the purine nucleoside analogue 2'-C-methyladenosine or the HCV protease inhibitor VX-950 resulted in an additive antiviral activity. These findings may have implications when planning clinical studies with valopicitabine.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00372-06

Authors: Lotte Coelmont, Jan Paeshuyse, Marc P. Windisch, Erik De Clercq, Ralf Bartenschlager, Johan Neyts

Institutions: Rega Institute for Medical Research, KU Leuven, Heidelberg University

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2129802492

FWCI: 6.19

Cites: 13

Cited by: 58

Related to: 10