RIPOSTE: a framework for improving the design and analysis of laboratory-based research
Year: 2015
Type: article
Abstract: Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contribute to this problem. The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, to reduce irreproducibility. This framework is intended for use during the early stages of a research project, when specific questions or hypotheses are proposed. The essential points within the framework are explained and illustrated using three examples (a medical equipment test, a macrophage study and a gene expression study). Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results.
Source: eLife
DOI: 10.7554/elife.05519
Authors: Nicholas GD Masca, Elizabeth MA Hensor, Victoria R Cornelius, Francesca M Buffa, Helen M Marriott, James M Eales, Michael P Messenger, Amy E Anderson, Chris Boot, Catey Bunce, Robert D Goldin, Jessica Harris, Rod F Hinchliffe, Hiba Junaid, Shaun Kingston, Carmen Martin-Ruiz, Christopher P Nelson, Janet Peacock, Paul T Seed, Bethany Shinkins, Karl J Staples, Jamie Toombs, Adam KA Wright, M Dawn Teare
Institutions: University of Leicester, University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, King's College London, University of Oxford, University of Sheffield, Leeds Teaching Hospitals NHS Trust, Newcastle University, Moorfields Eye Hospital NHS Foundation Trust, NIHR Moorfields Biomedical Research Centre, University College London, Imperial College London, University of Bristol, Sheffield Children's NHS Foundation Trust, Sheffield Children's Hospital, Royal London Hospital, Royal Brompton & Harefield NHS Foundation Trust, NIHR Leicester Cardiovascular Biomedical Research Unit, Guy's and St Thomas' NHS Foundation Trust, National Institute for Health and Care Research, Southampton General Hospital, NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton, UCL Queen Square Institute of Neurology, University Hospitals of Leicester NHS Trust
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W2135770010