Proliferative Expansion and Acquisition of Effector Activity by Memory CD4+ T Cells in the Lungs following Pulmonary Virus Infection
Year: 2008
Type: article
Abstract: The memory CD4+ T cell response to the respiratory syncytial virus (RSV) attachment (G) protein in the lungs of primed BALB/c mice undergoing challenge pulmonary RSV infection is dominated by effector T cells expressing a single Vbeta-chain, Vbeta14. We have used Vbeta14 expression to examine the kinetics of the activation, accumulation, and acquisition of the effector activity of memory CD4+ T cells responding to pulmonary infection. This analysis revealed that proliferative expansion and effector CD4+ T cell differentiation preferentially occur in the respiratory tract following rapid activation within and egress from the lymph nodes draining the respiratory tract. These findings suggest that, in response to natural infection at a peripheral mucosal site such as the lungs, memory CD4+ T cell expansion and differentiation into activated effector T cells may occur predominantly in the peripheral site of infection rather than exclusively in the lymph nodes draining the site of infection.
Source: The Journal of Immunology
Authors: Erika L Wissinger, Whitney W Stevens, Steven M Varga, Thomas J Braciale
Institutions: University of Virginia, University of Iowa
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: Immunobiology of Experimental RSV Infection, G3313402156, G3541620954, T Cell Function in Pulmonary Viral Pulmonary Infection and Injury, CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS, G597286701, Cytotoxic T Lymphocyte Response to Influenza Virus, CD8+ T cell trafficking to the normal lung, Interdisciplinary Training Program in Immunology, Infectious Diseases Training Program
OpenAlex ID: W2136277706