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Excellent Outcome for Fanconi Anemia Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT) without Radiation: A Single Center Experience on 103 Patients

Year: 2015

Type: article

Abstract: Fanconi anemia(FA) is a rare genetic disorder characterized by congenital defects, bone marrow failure and cancer predisposition. Over the past decade, survival after HSCT has greatly improved and the use of protocols without radiation are preferred in order to decrease late complications related to the development of head and neck cancer. In this study we analyzed 103 patients(pts) with FA who were transplanted between 2003 and 2014. The median age at HSCT was 9ys(range: 3-23ys). All pts were transplanted in marrow failure and received bone marrow from matched siblings (MSD) (n=49) or Alternative donors (AD) (n=54).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.114