Work

Chemical modification of anthracycline antibiotics. I. Demethoxycarbonylation, 10-epimerization and 4-o-methylation of aclacinomycin A.

Year: 1980

Type: article

Abstract: Demethoxycarbonyl derivatives of aclacinomycin A and of its 7-epimer, 10-epi-aclacinomycin A and 4-O-methylaclacinomycin A were chemically derived from aclacinomycin A. The cytotoxicity and inhibitory effects of RNA and DNA synthesis in cultured L1210 leukemia cells of the 4-O-methyl derivative approximated that of aclacinomycin A, while the demethoxycarbonyl derivatives and 10-epi-aclacinomycin A exhibited decreased activities in comparison with the parent compound.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.33.1323

Authors: HIROSHI TANAKA, TAKEO YOSHIOKA, YASUTAKA SHIMAUCHI, YASUE MATSUZAWA, TOSHIKAZU OKI, TAIJI INUI

Language: English

Topic: Bioactive Compounds and Antitumor Agents

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2136706649

FWCI: 6.338

Cites: 24

Cited by: 26

Related to: 10