Generation and Characterization of a Defined Mutant of Streptococcus suis Lacking Suilysin
Year: 2001
Type: article
Abstract: A defined allelic-replacement mutant of the sly gene, encoding a thiol-activated cytolysin, from a European isolate of Streptococcus suis serotype 2 was generated and characterized. Unlike the parental strain, it is nonhemolytic, noncytotoxic for cultured macrophage-like cells, avirulent in a mouse infection model, yet only slightly attenuated in a porcine model of systemic infection.
Source: Infection and Immunity
Institutions: University of Cambridge, The Pirbright Institute
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G8259179380
OpenAlex ID: W2136996256