Year: 2010
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The ratio of digit lengths is fixed in utero, and may be a proxy indicator for prenatal testosterone levels. METHODS: We analysed the right-hand pattern and prostate cancer risk in 1524 prostate cancer cases and 3044 population-based controls. RESULTS: Compared with index finger shorter than ring finger (low 2D : 4D), men with index finger longer than ring finger (high 2D : 4D) showed a negative association, suggesting a protective effect with a 33% risk reduction (odds ratio (OR) 0.67, 95% confidence interval (CI) 0.57-0.80). Risk reduction was even greater (87%) in age group <60 (OR 0.13, 95% CI 0.09-0.21). CONCLUSION: Pattern of finger lengths may be a simple marker of prostate cancer risk, with length of 2D greater than 4D suggestive of lower risk.
Source: British Journal of Cancer
Authors: The UK Genetic Prostate Cancer Study Collaborators, A A Rahman, A Lophatananon, S Stewart-Brown, D Harriss, J Anderson, T Parker, D Easton, Z Kote-Jarai, R Pocock, D Dearnaley, M Guy, L O'Brien, R A Wilkinson, A L Hall, E Sawyer, E Page, J-F Liu, R A Eeles, K Muir
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
OpenAlex ID: W2137229853