Work

In Vivo Evaluation of Hydroxyapatite Foams

Year: 2002

Type: article

Abstract: Porous hydroxyapatite manufactured by foaming of aqueous ceramic suspensions and setting via gelcasting of organic monomers was tested for in vivo biocompatibility in rabbit tibia for a period of 8 weeks. The foams provide tortous frameworks and large interconnected pores that support cell attachment and organisation into 3D arrays to form new tissue. The HA foam implants were progressively filled with mature new bone tissue and osteoid after the implanted period, confirming the high osteoconductive potential and high biocompatibility of HA and the suitability of foam network in providing good osteointegration. No immune or inflammatory reactions were detected.

Source: Materials Research

DOI: 10.1590/s1516-14392002000300006

Authors: P. Sepulveda, A.H. Bressiani, J.C. Bressiani, L. Meseguer, B. König Jr

Institutions: Instituto de Pesquisas Energéticas e Nucleares, National Nuclear Energy Commission, Universidad de Murcia

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Fundação de Amparo à Pesquisa do Estado de São Paulo