Work

Synthesis, Antibacterial, Anthelmintic and Anti-Inflammatory Studies of Novel Methylpyrimidine Sulfonyl Piperazine Derivatives

Year: 2014

Type: article

Abstract: A strategic synthesis of novel methylpyrimidine sulfonyl piperazines involving Suzuki coupling was designed and pharmacological activities of the compounds were evaluated. Reactions were carried out under conventional method and show good functional group transformations and high yields. Structures of the newly synthesized compounds were established by infrared spectroscopy (IR), ¹H and 13C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) and elemental analysis. The compounds were tested for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains, anthelmintic activity using Pheretima posthuma and anti-inflammatory activity involving carrageenan induced rat paw edema model. Some compounds were proven to be potent pharmacophores.

Source: Journal of the Brazilian Chemical Society

DOI: 10.5935/0103-5053.20140073

Authors: Nadigar R. Mohan, Swamy Sreenivasa, Karikere E. Manojkumar, Tadimety M. C. Rao, Boreddy S. Thippeswamy, Parameshwar A. Suchetan

Institutions: Tumkur University, Tata Chemicals (India), Torrent Pharma (India), SODA Aromatic Co., Ltd. (Japan)

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $275