Work

Neuroprotection and Reduced Proliferation of Microglia in Ribavirin-Treated Bornavirus-Infected Rats

Year: 2002

Type: article

Abstract: In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1beta (IL-1beta), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.46.7.2287-2291.2002

Authors: Marylou V. Solbrig, Robert Schlaberg, Thomas Briese, Nigel Horscroft, W. Ian Lipkin

Institutions: University of California, Irvine, University of Würzburg, Orange County Department of Education

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke